Predictive value of serum markers for the development of interstitial lung disease in patients with polymyositis and dermatomyositis: a comparative and prospective study
Identifieur interne : 000F31 ( Main/Exploration ); précédent : 000F30; suivant : 000F32Predictive value of serum markers for the development of interstitial lung disease in patients with polymyositis and dermatomyositis: a comparative and prospective study
Auteurs : F. Chen [République populaire de Chine] ; X. Lu [République populaire de Chine] ; X. Shu [République populaire de Chine] ; Q. Peng [République populaire de Chine] ; X. Tian [République populaire de Chine] ; G. Wang [République populaire de Chine]Source :
- Internal Medicine Journal [ 1444-0903 ] ; 2015-06.
Abstract
Background: Interstitial lung disease (ILD) is one of the most common and devastated complication of polymyositis/dermatomyositis (PM/DM). Several studies have focused on serum biomarkers for ILD in PM/DM patients; however, there have been no prospective studies. Aim: To explore and compare the predictive value of four serum markers for the development of ILD in patients with PM/DM. Methods: One hundred adult PM/DM patients were included in this prospective clinical study at baseline. Forty‐four PM/DM patients without ILD were followed up for 1 year. Fifty‐six PM/DM patients with ILD were treated and followed up for 2 months. Serum samples were analysed for the levels of Krebs von den Lungen‐6 (KL‐6), monocyte chemotactic protein‐1 (MCP‐1), surfactant protein‐A and D (SP‐A, SP‐D). Results: Serum KL‐6 (1542.8 ± 760.8 U/mL) (P < 0.001), MCP‐1 (1870 ± 1590 pg/mL) (P = 0.014), SP‐A (56 ± 28 ng/mL) (P < 0.001) and SP‐D (230 ± 196 ng/mL) (P < 0.001) were significantly elevated in PM/DM patients with ILD compared with those in the patients without ILD (KL‐6 429 ± 105.8 U/mL; MCP‐1 1349 ± 1303 pg/mL; SP‐A 34 ± 26 ng/mL; SP‐D 96 ± 63 ng/mL). In PM/DM patients without ILD who were followed up for 1 year, KL‐6 presented the highest predictive value among single markers. In patients who were treated and followed up, KL‐6 concentrations increased with the progression of ILD and decreased along with the improvement of ILD. Conclusion: Considering the ability of KL‐6 for predicting the onset of ILD and monitoring the treatment response of ILD in PM/DM patients, it may be of great significance for clinical practice, and the prognosis of patients may be substantially improved if serum KL‐6 was regularly monitored.
Url:
DOI: 10.1111/imj.12754
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001596
- to stream Istex, to step Curation: 001596
- to stream Istex, to step Checkpoint: 000076
- to stream Main, to step Merge: 000F32
- to stream Main, to step Curation: 000F31
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Predictive value of serum markers for the development of interstitial lung disease in patients with polymyositis and dermatomyositis: a comparative and prospective study</title><author><name sortKey="Chen, F" sort="Chen, F" uniqKey="Chen F" first="F." last="Chen">F. Chen</name></author><author><name sortKey="Lu, X" sort="Lu, X" uniqKey="Lu X" first="X." last="Lu">X. Lu</name></author><author><name sortKey="Shu, X" sort="Shu, X" uniqKey="Shu X" first="X." last="Shu">X. Shu</name></author><author><name sortKey="Peng, Q" sort="Peng, Q" uniqKey="Peng Q" first="Q." last="Peng">Q. Peng</name></author><author><name sortKey="Tian, X" sort="Tian, X" uniqKey="Tian X" first="X." last="Tian">X. Tian</name></author><author><name sortKey="Wang, G" sort="Wang, G" uniqKey="Wang G" first="G." last="Wang">G. Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:249174A4FE3F03904034F8D234EFBBD08C7B3A72</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1111/imj.12754</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-ZKV2GC5X-V/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001596</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001596</idno><idno type="wicri:Area/Istex/Curation">001596</idno><idno type="wicri:Area/Istex/Checkpoint">000076</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000076</idno><idno type="wicri:doubleKey">1444-0903:2015:Chen F:predictive:value:of</idno><idno type="wicri:Area/Main/Merge">000F32</idno><idno type="wicri:Area/Main/Curation">000F31</idno><idno type="wicri:Area/Main/Exploration">000F31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Predictive value of serum markers for the development of interstitial lung disease in patients with polymyositis and dermatomyositis: a comparative and prospective study</title><author><name sortKey="Chen, F" sort="Chen, F" uniqKey="Chen F" first="F." last="Chen">F. Chen</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology, China‐Japan Friendship Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lu, X" sort="Lu, X" uniqKey="Lu X" first="X." last="Lu">X. Lu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology, China‐Japan Friendship Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Shu, X" sort="Shu, X" uniqKey="Shu X" first="X." last="Shu">X. Shu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology, China‐Japan Friendship Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Peng, Q" sort="Peng, Q" uniqKey="Peng Q" first="Q." last="Peng">Q. Peng</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology, China‐Japan Friendship Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tian, X" sort="Tian, X" uniqKey="Tian X" first="X." last="Tian">X. Tian</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology, China‐Japan Friendship Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, G" sort="Wang, G" uniqKey="Wang G" first="G." last="Wang">G. Wang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rheumatology, China‐Japan Friendship Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Internal Medicine Journal</title><title level="j" type="alt">INTERNAL MEDICINE JOURNAL</title><idno type="ISSN">1444-0903</idno><idno type="eISSN">1445-5994</idno><imprint><biblScope unit="vol">45</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="641">641</biblScope><biblScope unit="page" to="647">647</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2015-06">2015-06</date></imprint><idno type="ISSN">1444-0903</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1444-0903</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Interstitial lung disease (ILD) is one of the most common and devastated complication of polymyositis/dermatomyositis (PM/DM). Several studies have focused on serum biomarkers for ILD in PM/DM patients; however, there have been no prospective studies. Aim: To explore and compare the predictive value of four serum markers for the development of ILD in patients with PM/DM. Methods: One hundred adult PM/DM patients were included in this prospective clinical study at baseline. Forty‐four PM/DM patients without ILD were followed up for 1 year. Fifty‐six PM/DM patients with ILD were treated and followed up for 2 months. Serum samples were analysed for the levels of Krebs von den Lungen‐6 (KL‐6), monocyte chemotactic protein‐1 (MCP‐1), surfactant protein‐A and D (SP‐A, SP‐D). Results: Serum KL‐6 (1542.8 ± 760.8 U/mL) (P < 0.001), MCP‐1 (1870 ± 1590 pg/mL) (P = 0.014), SP‐A (56 ± 28 ng/mL) (P < 0.001) and SP‐D (230 ± 196 ng/mL) (P < 0.001) were significantly elevated in PM/DM patients with ILD compared with those in the patients without ILD (KL‐6 429 ± 105.8 U/mL; MCP‐1 1349 ± 1303 pg/mL; SP‐A 34 ± 26 ng/mL; SP‐D 96 ± 63 ng/mL). In PM/DM patients without ILD who were followed up for 1 year, KL‐6 presented the highest predictive value among single markers. In patients who were treated and followed up, KL‐6 concentrations increased with the progression of ILD and decreased along with the improvement of ILD. Conclusion: Considering the ability of KL‐6 for predicting the onset of ILD and monitoring the treatment response of ILD in PM/DM patients, it may be of great significance for clinical practice, and the prognosis of patients may be substantially improved if serum KL‐6 was regularly monitored.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, F" sort="Chen, F" uniqKey="Chen F" first="F." last="Chen">F. Chen</name></noRegion><name sortKey="Lu, X" sort="Lu, X" uniqKey="Lu X" first="X." last="Lu">X. Lu</name><name sortKey="Peng, Q" sort="Peng, Q" uniqKey="Peng Q" first="Q." last="Peng">Q. Peng</name><name sortKey="Shu, X" sort="Shu, X" uniqKey="Shu X" first="X." last="Shu">X. Shu</name><name sortKey="Tian, X" sort="Tian, X" uniqKey="Tian X" first="X." last="Tian">X. Tian</name><name sortKey="Wang, G" sort="Wang, G" uniqKey="Wang G" first="G." last="Wang">G. Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F31 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F31 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:249174A4FE3F03904034F8D234EFBBD08C7B3A72
|texte= Predictive value of serum markers for the development of interstitial lung disease in patients with polymyositis and dermatomyositis: a comparative and prospective study
}}
| This area was generated with Dilib version V0.6.33. |  |